Progetti Presentati 2011/2012

• Genomic charateristics of regulatory t-cells in chronic lymphocytic leukemia: relationship to clinical outcome and potential implication for treatment.
  Principal Investigator: Giovanni D'Arena

• Human oncogenic risk from consumptions of beef red meat.
  Principal Investigator: Rocco Galasso

• New molecular mechanisms responsible for drug resistance and novel biomarkers predictive of the individual response to therapy in human breast and ovarian carcinomas.
  Principal Investigator: Matteo Landriscina

• Development of an Italian network to optimize clinical management and resource use in myelodysplastic syndromes.
  Principal Investigator: Pellegrino Musto

• Spatially variant prescription of dose radiation from hypoxic tumor distribution assessed by VEGF expression and biological imaging: a phases I-II study in non small cell lung cancer.
  Principal Investigator: Antonio Nappi

• Role of mitochondrial oxidative metabolism and redox signaling in adult stem cell proliferation and differentiation: development of innovative strategies for ex vivo hematopoietic stem cell expansion to be used in onco-hematological therapies.
  Principal Investigator: Claudia Piccoli

• Radiation exposure optimization by wireless technology for professionals involved in the management and care of patients undergoing therapy with radionuclides. Implementation of environmental monitoring.
  Principal Investigator: Giovanni Storto

Giovani Ricercatori

• Trop-2 in metastatic diffusion to organ-specific niches: molecular mechanisms and trnslational impact of anti-Trop-2-agents.
  Principal Investigator: Marco Trerotola

• Identification of epha3 as a new molecular target in multiple myeloma: opportunity for a novel therapeutc approach with a spcific monoclonal antibody.
  Principal Investigator: Antonella Caivano

• Hematopoietic stem cells methylation profile after transplantation: role in influencing transplant biology.
  Principal Investigator: Annalisa Morano

• Role of Lin28 in acute myeloid leukemia.
  Principal Investigator: Luciana De Luca